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  Photoacoustic Imaging


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    Image reconstruction

    Photoacoustic propagation     models

    Quantitative photoacoustic     spectroscopy

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    Guide to FP ultrasound sensing

    Fibre optic hydrophone

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    UCL Dept of Medical Physics &     Bioengineering




 Photoacoustic Imaging Group                                                BORL

Latest 3D photoacoustic images - to see more and find out how these were obtained, click here

The Photoacoustic Imaging Goup was founded in 2002 and forms a sub-group of the UCL Biomedical Optics Research Laboratory, BORL. It currently comprises 17 researchers, funded through a combination of UK research council grants and industrial sponsorship. Our activities are directed towards the development of a promising new method of non-invasive biomedical imaging based upon the use of laser-generated acoustic waves for visualising the internal structure and function of soft tissues. Potential applications include the clinical assessment of breast cancer, vascular disease and skin abnormalities. The technique also has important applications as a research tool in the basic life sciences for undertaking molecular and genomic imaging studies, for example studying tumour physiology. Our current research encompasses the full range of activities in photoacoustic methods: photoacoustic detection and excitation instrumentation, modelling of photoacoustic signals, image reconstruction algorithms, spectroscopic methods and the application of the technique in the clinical and life sciences.

In addition to biomedical photoacoustic imaging, a range of ultrasound field measurement and imaging tools based upon the use of Fabry Perot polymer film sensing interferometers is being developed. These include a miniature wideband fibre optic hydrophone for characterising medical and industrial ultrasound fields and high speed 2D arrays for field visualisation and imaging applications in medicine and industrial NDT.


Latest additions

star4star3 Postdoctoral research positions available star2star1 further details to follow

k-Wave - a Matlab toolbox for the simulation of photoacoustic and ultrasound fields


Recently published articles:

Noimark S, Colchester RJ, Blackburn BJ, Zhang EZ, Alles EJ, Ourselin S, Beard PC, Papakonstantinou I, Parkin IP and Desjardins AE (2016), Carbon-Nanotube-PDMS Composite Coatings on Optical Fibers for All-Optical Ultrasound Imaging, Advanced Functional Materials doi:10.1002/adfm.201601337 Download PDF file

Alles EJ, Noimark S, Zhang E, Beard PC, Desjardins AE (2016), Pencil beam all-optical ultrasound imaging, Biomedical Optics Express 7(9) 3696-3704 Download PDF file

Schneider C, Johnson SP, Walker-Samuel S, Gurusamy K, Clarkson MJ, Thompson S, Song Y, Totz J, Cook RJ, Desjardins AE, Hawkes DJ, Davidson (2016), Utilizing confocal laser endomicroscopy for evaluating the adequacy of laparoscopic liver ablation, Lasers in Surgery and Medicine 48(3) 299-310 Download PDF file

Mazomenos EB, Chang P-L, Rippel RA, Rolls A, Hawkes DJ, Bicknell CD, Desjardins A, Riga CV, Stoyanov D (2016), Catheter manipulation analysis for objective performance and technical skills assessment in transcatheter aortic valve implantation, International Journal of Computer Assisted Radiology and Surgery 11(6) 1121-31 Download PDF file

Nam H, Zhang EZ, Betcke M, Arrridge S, Beard PC, Cox B (2016), Single-Pixel Optical Camera for Video Rate Ultrasonic Imaging, Optica 3(1) 26-29 Download PDF file

Brunker B, Beard PC (2016), Velocity measurements in whole blood using acoustic resolution photoacoustic Doppler, Biomedical Optics Express 7(7) 2789-2806 Download PDF file

Fonseca M, Zeqiri B, Beard PC, Cox BT (2016), Characterisation of a phantom for multiwavelength quantitative photoacoustic imaging, Physics in Medicine and Biology 61(13) 4950-4973. Download PDF file

Xia W, Ginsberg Y, West SJ, Nikitichev DI, Ourselin S, David AL, Desjardins AE (2016), Coded excitation ultrasonic needle tracking: An in vivo study, Medical Physics 43(7) 4065-73 Download PDF file

Nikitichev DI, Xia W, Mosse CA, Perkins T, Konyn K, Ourselin S, Desjardins AE, Vercauteren T (2016), Music-of-light stethoscope: a demonstration of the photoacoustic effect, Physics Education 51(4) 045015 Download PDF file

Nikitichev DI, Barburas A, McPherson K, Mari JM, West SJ, Desjardins AE (2016), Construction of 3-Dimensional Printed Ultrasound Phantoms With Wall-less Vessels, Journal of Ultrasound in Medicine 35(6) 1333-9 Download PDF file

Brunker B, Beard P (2016), Acoustic resolution photoacoustic Doppler velocimetry in blood-mimicking fluids, Scientific Reports 6 20902 Download PDF file

Alles EJ, Colchester RJ, and Desjardins AE (2016), Adaptive Light Modulation for Improved Resolution and Efficiency in All-Optical Pulse-Echo Ultrasound, IEEE Transactions on Ultrasound, Ferroelectrics and frequency control 63(1), 83-90 Download PDF file

Mari JM, Xia W, West SJ, Desjardins AE (2015) Interventional multispectral photoacoustic imaging with a clinical ultrasound probe for discriminating nerves and tendons: an ex vivo pilot study, Journal of Biomedical Optics 20(11) 110503 Download PDF file

Xia W, Mari JM, West SJ, Ginsberg Y, David AL, Ourselin S, Desjardins AE (2015) In-plane ultrasonic needle tracking using a fiber-optic hydrophone, Medical Physics 42(10) 5983-5991 Download PDF file

d’Esposito A, Nikitichev D, Desjardins A, Walker-Samuel S, Lythgoe MF (2015) Quantification of light attenuation in optically cleared mouse brains, Journal of Biomedical Optics 20(8) 080503 Download PDF file

Schneider C, Desjardins AE, Gurusamy K, Hawkes DJ and Davidson BR (2015) Laparoscopic manipulation of a probe-based confocal laser endomicroscope using a steerable intravascular catheter, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25(2) e83-e85 Download PDF file

Xia W, Nikitichev DI, Mari JM, West SJ, Pratt R, David AL, Ourselin S, Beard PC and Desjardins AE (2015) Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures, Journal of Biomedical Optics 20(8) 086005 Download PDF file

Jathoul AP, Laufer J, Ogunlade O, Treeby B, Cox B, Zhang E, Johnson P, Pizzey AR, Philip B, Marafioti T, Lythgoe MF, Pedley RB, Pule MA and Beard P (2015) Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter, Nature Photonics 9, 239-246 Download PDF file

Guggenheim JA, Allen TJ, Plumb A, Zhang EZ, Rodriguez-Justo M, Punwani S and Beard PC (2015) Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast, Journal of Biomedical Optics 20(5) 050504 Download PDF file

Colchester RJ, Zhang EZ, Mosse CA, Beard PC, Papakonstantinou I and Desjardins A (2015) Broadband miniature optical ultrasound probe for high resolution vascular tissue imaging, Biomedical Optics Express 6(4), 1502�1511 Download PDF file

Ogunlade O and Beard P (2015) Exogenous contrast agents for thermoacoustic imaging: An investigation into the underlying sources of contrast. Medical Physics 42, 170-181 Download PDF file

For a full list of publications, click here


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