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  Photoacoustic Imaging


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    Image reconstruction

    Photoacoustic propagation     models

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    UCL Dept of Medical Physics &     Bioengineering




 Photoacoustic Imaging Group                                                BORL

Latest 3D photoacoustic images - to see more and find out how these were obtained, click here

The Photoacoustic Imaging Goup was founded in 2002 and forms a sub-group of the UCL Biomedical Optics Research Laboratory, BORL. It currently comprises 17 researchers, funded through a combination of UK research council grants and industrial sponsorship. Our activities are directed towards the development of a promising new method of non-invasive biomedical imaging based upon the use of laser-generated acoustic waves for visualising the internal structure and function of soft tissues. Potential applications include the clinical assessment of breast cancer, vascular disease and skin abnormalities. The technique also has important applications as a research tool in the basic life sciences for undertaking molecular and genomic imaging studies, for example studying tumour physiology. Our current research encompasses the full range of activities in photoacoustic methods: photoacoustic detection and excitation instrumentation, modelling of photoacoustic signals, image reconstruction algorithms, spectroscopic methods and the application of the technique in the clinical and life sciences.

In addition to biomedical photoacoustic imaging, a range of ultrasound field measurement and imaging tools based upon the use of Fabry Perot polymer film sensing interferometers is being developed. These include a miniature wideband fibre optic hydrophone for characterising medical and industrial ultrasound fields and high speed 2D arrays for field visualisation and imaging applications in medicine and industrial NDT.


Latest additions

star4star3 Postdoctoral research positions available star2star1 further details to follow

k-Wave - a Matlab toolbox for the simulation of photoacoustic and ultrasound fields


Recently published articles:

Mari JM, Xia W, West SJ, Desjardins AE (2015) Interventional multispectral photoacoustic imaging with a clinical ultrasound probe for discriminating nerves and tendons: an ex vivo pilot study, Journal of Biomedical Optics 20(11) 110503 Download PDF file

Xia W, Mari JM, West SJ, Ginsberg Y, David AL, Ourselin S, Desjardins AE (2015) In-plane ultrasonic needle tracking using a fiber-optic hydrophone, Medical Physics 42(10) 5983-5991 Download PDF file

d’Esposito A, Nikitichev D, Desjardins A, Walker-Samuel S, Lythgoe MF (2015) Quantification of light attenuation in optically cleared mouse brains, Journal of Biomedical Optics 20(8) 080503 Download PDF file

Schneider C, Desjardins AE, Gurusamy K, Hawkes DJ and Davidson BR (2015) Laparoscopic manipulation of a probe-based confocal laser endomicroscope using a steerable intravascular catheter, Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25(2) e83-e85 Download PDF file

Xia W, Nikitichev DI, Mari JM, West SJ, Pratt R, David AL, Ourselin S, Beard PC and Desjardins AE (2015) Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures, Journal of Biomedical Optics 20(8) 086005 Download PDF file

Jathoul AP, Laufer J, Ogunlade O, Treeby B, Cox B, Zhang E, Johnson P, Pizzey AR, Philip B, Marafioti T, Lythgoe MF, Pedley RB, Pule MA and Beard P (2015) Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter, Nature Photonics 9, 239-246 Download PDF file

Guggenheim JA, Allen TJ, Plumb A, Zhang EZ, Rodriguez-Justo M, Punwani S and Beard PC (2015) Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast, Journal of Biomedical Optics 20(5) 050504 Download PDF file

Colchester RJ, Zhang EZ, Mosse CA, Beard PC, Papakonstantinou I and Desjardins A (2015) Broadband miniature optical ultrasound probe for high resolution vascular tissue imaging, Biomedical Optics Express 6(4), 1502–1511 Download PDF file

Ogunlade O and Beard P (2015) Exogenous contrast agents for thermoacoustic imaging: An investigation into the underlying sources of contrast. Medical Physics 42, 170-181 Download PDF file

West SJ, Mari J-M, Khan A, Wan JHY, Zhu W, Koutsakos IG, Rowe M, Kamming D, Desjardins AE (2014). Development of an Ultrasound Phantom for Spinal Injections with 3-Dimensional Printing. Regional Anesthesia and Pain Management 39(5), 429-343 Download PDF file

Colchester RJ, Mosse CA, Bhachu DS, Bear JC, Carmalt CJ, Parkin IP, Treeby BE, Papakonstantinou I and Desjardins AE (2014) Laser-generated ultrasound with optical fibres using functionalised carbon
nanotube composite coatings, Applied Physics Letters 104(17), 173502 Download PDF file

Laufer J, Jathoul A, Pule M and Beard P (2013) In vitro characterization of genetically expressed absorbing proteins using photoacoustic spectroscopy, Biomedical Optics Express 4(11), 2477-2490 Download PDF file

Saratoon T, Tarvainen T, Cox BT and Arridge SR (2013) A gradient-based method for quantitative photoacoustic tomography using the radiative transfer equation, Inverse Problems 29(7), 075006 Download PDF file

Treeby B (2013) Acoustic attenuation compensation in photoacoustic tomography using time-variant filtering, Journal of Biomedical Optics 18(3), 036008 Download PDF file

Firouzi K, Cox BT, Treeby BE and Saffari N (2012) A first-order k-space model for elastic wave propagation in heterogeneous media, Journal of the Acoustical Society of America, 132(3), 1271-1283 Download PDF file

Brunker J and Beard P (2012) Pulsed photoacoustic Doppler flowmetry using time-domain cross-correlation: Accuracy, resolution and scalability, Journal of the Acoustical Society of America, 132(3), 1780-1791 Download PDF file

Cox B, Laufer JG, Arridge SR, Beard PC (2012) Quantitative spectroscopic photoacoustic imaging: a review, Journal of Biomedical Optics 17(6), 061202 Download PDF file

Laufer J, Johnson P, Zhang E, Treeby B, Cox B, Pedley B, Beard P (2012) In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy, Journal of Biomedical Optics 17(5), 056016 Download PDF file

Allen TJ, Hall A, Dhillon AP, Owen JS, Beard PC (2012) Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range, Journal of Biomedical Optics 17(6), 061209 Download PDF file

Laufer J, Norris F, Cleary J, Zhang E, Treeby B, Cox B, Johnson P, Scambler P, Lythgoe M, Beard P (2012) In vivo photoacoustic imaging of mouse embryos, Journal of Biomedical Optics 17(6), 061220 Download PDF file

Beard PC (2011) Biomedical Photoacoustic Imaging, Interface Focus, 1(4), 602-631 Download PDF file

Zhang EZ, Povazay B, Laufer J, Alex A, Hofer B, Pedley B, Glittenberg C, Treeby B, Cox B, Beard P, and Drexler W (2011) Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging, Biomedical Optics Express, 2(8), 2202-2215 Download PDF file

Treeby BE, Tumen M, and Cox BT (2011) Time domain simulation of harmonic ultrasound images and beam patterns in 3D using the k-space pseudospectral method, MICCAI, Part I, Vol. 6891, pp. 369-376 (Springer, Heidelberg)

Treeby BE, Varslot TK, Zhang EZ, Laufer JG, Beard PC (2011) Automatic sound speed selection in photoacoustic image reconstruction using an autofocus approach, Journal of Biomedical Optics 16, 090501 Download PDF file

Treeby BE, Zhang EZ, Thomas AS, Cox BT (2011) Measurement of the ultrasound attenuation and dispersion in whole human blood and its components from 0-70MHz, Ultrasound in Medicine and Biology 37(2), 289-300 Download PDF file

Treeby BE, Zhang EZ, Cox BT (2010) Photoacoustic tomography in absorbing acoustic media using time reversal, Inverse Problems, 26(11), 115003 Download PDF file

Laufer J, Zhang E, Beard P (2010) Evaluation of absorbing chromophores used in tissue phantoms for quantitative photoacoustic spectroscopy and imaging, Journal of Selected Topics in Quantum Electronics, 16(3), 600-608 Download PDF file

Cox BT, Laufer JG, Beard PC (2010) Quantitative photoacoustic image reconstruction using fluence dependent absorbers, Biomedical Optics Express, 1(1), 201-208 Download PDF file

Treeby BE and Cox BT (2010) Modelling power law absorption and dispersion for acoustic propagation using the fractional Laplacian, Journal of the Acoustical Society of America, 127(5), 2741-2748 Download PDF file

Cox BT, Treeby BE (2010) Artifact trapping during time reversal photoacoustic imaging for acoustically heterogeneous media, IEEE Transactions on Medical Imaging, 29(2), 387-396 Download PDF file

Laufer J, Cox B, Zhang Z, Beard P (2010) Quantitative determination of chromophore concentrations from 2D photoacoustic images using a nonlinear model-based inversion scheme, Applied Optics, 49(8), 1219-1233 Download PDF file

Treeby BE, Cox BT (2010) k-Wave: MATLAB toolbox for the simulation and reconstruction of photoacoustic wave fields, Journal of Biomedical Optics, 15(2), 021314 Download PDF file

Treeby BE, and Pan J (2009) A practical examination of the errors arising in the direct collocation boundary element method of acoustic scattering, Engineering Analysis with Boundary Elements 33, 1302-1315 Download PDF file

Treeby BE, Cox BT, Zhang EZ, Patch SK, Beard PC (2009) Measurement of broadband temperature-dependent ultrasonic attenuation and dispersion using photoacoustics, IEEE Transactions on Ultrasound, Ferroelectrics and frequency control 56(8), 1666-1676 Download PDF file

Morris P, Hurrell A, Shaw A, Zhang E, Beard P (2009) A Fabry–Pérot fiber-optic ultrasonic hydrophone for the simultaneous measurement of temperature and acoustic pressure, J. Acoust. Soc. Am. 125(6), 3611-3622 Download PDF file

Cox BT, Arridge SR, Beard PC, (2009) Estimating chromophore distributions from multiwavelength photoacoustic images, Journal of the Optical Society of America A, 26(2), 443-445. Download PDF file

Cox BT, Beard PC (2009) Photoacoustic tomography with a single detector in a reverberant cavity, Journal of the Acoustical Society of America, 25(3), 1426-1436. Download PDF here

Zhang EZ, Laufer JG, Pedley RB, Beard PC (2009) In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy, Physics in Medicine and Biology, 54, 1035-1046. Download PDF file

Laufer J, Zhang E, Raivich G, Beard P (2009) Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner, Applied Optics, 48(10), D299-D306.
Download PDF file

Zhang, E, Laufer, J, Beard, P (2008): Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues, Applied Optics 47, 561-577. Download PDF file

For a full list of publications, click here


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