Louise Enfield

Biomedical Optics Research Lab
Dept. of Medical Physics, UCL
Malet Place Engineering Building
LONDON, WC1E 6BT

Tel (44-20) 7679 0203

Fax: (44-20) 7679-6269

I joined BORL in the Department of Medical Physics and Bioengineering in June 2004 to work on the 3D optical imaging of breasts, supported by CRUK, using MONSTIR.

From June 2007 to Dec 2008 I was by the EPSRC, using MONSTIR and NIR light to look at brain injury and brain development in neonates.

I am currently employed as part of the UCL/KCL Cancer Imaging Centre, supported by CRUK, EPSRC, MRC and the Department of Health. I am working on project following women undergoing neoadjuvant chemotherapy using optical imaging. We aim to scan women prior to treatment and at various time points duing the course of the treatment. We aim to see if changes in haemoglobin concetration and oxygem saturation in the tumour can be imaged using NIR optical mammography and used to predict the outcome to treatment.

I am also involved in some teaching in the department, mainly of neurophysiology and optical imaging, on M.Sc. BEMI, M.Sc. Radiation Physics and the undergraduate course MPHY1882, Essential Medical Physics.

For work I use a number of programs to analyse and process data, the use of which are described here Viewdata, Xwin and Monstix

Education

I completed a Ph.D. with the Department of Clinical Neurophysiology at UCL on Electrical Impedance Tomography of Brain Function in February 2006.

My Ph.D. covered four areas of research, both laboratory and clinically based as a member of multi-disciplinary team. These areas of research included the testing of four commercially available
headnets, the recording of neuronal depolarisation , Electrical Impedance Tomography of interictal activity and Multifrequency Electrical Impedance Tomography.

Prior to this, I did a M.Sc. in Human and Applied Physiology at Kings College London, finishing in 2000. I studied cardiovascular, respiratory and muscle physiology, as well as aviation, hyper- and hypo-baric and thermal physiology.

Before that I completed a B.Sc. (Hons.) in Physiology at University of St Andrews in 1999.

Publications

Publications and Conference Proceedings

Enfield LC, Gibson AP, Hebden JC and Douek M "Optical Tomography of Breast Cancer - monitoring response to primary medical therapy" Targeted Oncology Download PDF
Cooper RJ, Everdell NL, Enfield LC, Gibson AP, Worley A, and Hebden JC (2009): Design and evaluation of a probe for simultaneous EEG and near-infrared imaging of cortical activation. Physics in Medicine and Biology 54, 2093-2102 Download PDF File.

LC Enfield, AP Gibson, NL Everdell, JC Hebden, SR Arridge, A Sharma, RS Sainsbury, M Douek and MRS Keshtgar "Sensitivity and Specificity of 3D Optical Mammography", Technical digest of OSA Biomedical Optics Topical Meetings (Optical Society of America, Washington DC, 2008).

Leff DR, Warren O, Enfield LC, Gibson AP, Athanasiou T, Pattern DK, Hebden JC, Yang GZ, and Darzi A (2008): Diffuse optical imaging of the healthy and diseased breast - a systematic review, Breast Cancer Research and Treatment 108 (1) 9–22 Download PDF file

Louise C Enfield, Adam P. Gibson,Nicholas L. Everdell, David T. Delpy,Martin Schweiger, Simon R. Arridge,Caroline Richardson,Mohammad Keshtgar,Michael Douek and Jeremy C. Hebden "Three-dimensional time-resolved optical mammography of the uncompressed breast" Applied Optics 46 (17) pp. 3628-3638 (2007) [Download PDF]
L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, and J. C. Hebden, S. R. Arridge, M. Douek, and M. R. S Keshtgar, "Three-dimensional time-resolved optical mammography of the uncompressed breast", Technical digest of OSA Biomedical Optics Topical Meetings (Optical Society of America, Washington DC, 2006).
Yates TD, Hebden JC, Gibson AP, Enfield L, Everdell NL, Arridge SR, and Delpy DT (2005): "Time-resolved optical mammography using a liquid coupled interface", Journal of Biomedical Optics 10(5), 054011. Download PDF file.

Enfield L & Holder DS (2002). "Electrical impedance tomography of brain function: overview and technical considerations". Int Journal Bioelectromagnetism 4, 199 - 200.

Liston A; Bayford R; Holder D and Enfield L. 2001. Rapid imaging of neuronal depolarisation in the brain by Electrical Impedance Tomography: an estimate of likely signal magnitude.

A D Liston; R H Bayford; D S Holder and L C Enfield, 2001. A Model of Resistance Change in the Human Cortex During Neuronal Depolarisation. XI International Conference on Electrical Bio-Impedance, Oslo Neuroimage 13, Number 6, Part 2 of 2. Page S1268. ISSN 1053-8119.

Posters and Oral Communications

L. C. Enfield, A. P. Gibson, N. L. Everdell, and J. C. Hebden S. R. Arridge, A. Sharma, R. S. Sainsbury, M. Douek and M. R. S Keshtgar "Sensitivity and Specificity of 3D Optical Mammography", poster Presentation, OSA Biomedical Optics Topical Meeting, St. Petersburg, March 2008

Sharma A, Enfield L, Gibson AP, Everdell NL, Schweiger M,Arridge S, Delpy DT, Hebden JC, Keshtgar M, Sainsbury RS and Douek M "Breast optical tomography: sensitivities and specificities for the detection of cancer": Poster Presentation, 30th Annual San Antonio Breast Cancer Symposium, December 13–16, 2007.

Sharma A, Enfield L, Gibson AP, Everdell NL, Schweiger M,Arridge S, Delpy DT, Hebden JC, Keshtgar M, Sainsbury RSand Douek M "Breast optical tomography: sensitivities and specificities for the detection of cancer": Poster Presentation, BASO ~ ACS Joint Scientific Conference, London, England, November 2007

Richardson CE, Enfield L, Gibson AP, Everdell NL, Hebden JC, Arridge SR, Delpy DT, Keshtgar MR, Sainsbury R, Douek M. "Imaging Breast Cancer Non-invasively Using Three Dimensional Optical Tomography". Poster presentation, British Association of Surgical Oncologists, London, England, November 2006.

Richardson CE, Enfield L, Gibson AP, Everdell NL, Hebden JC, Arridge SR, Delpy DT, Keshtgar M, Douek M. "Three Dimensional Optical Imaging of the Breast". Poster Presentation, SET for Britain Awards, House of Commons, London, England, March 2006. Highly Commended Award

Richardson CE, Enfield L, Gibson AP, Everdell NL, Hebden JC, Arridge SR, Keshtgar MR, Sainsbury R, Douek M."Non-Invasive Optical Imaging in Patients with Breast Cancer".Poster presentation, European Society of Surgical Oncologists, Venice, Italy, December 2006.

Richardson CE, Enfield L, Gibson AP, Everdell NL, Hebden JC, Arridge SR, Delpy DT, Keshtgar MR, Sainsbury R, Douek M. "Non-Invasive Three Dimensional Optical Mammography". Poster presentation.8th Milan Breast Cancer Conference, Milan, Italy, June 2006.

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, and J. C. Hebden, S. R. Arridge, M. Douek, and M. R. S Keshtgar, "Three-dimensional time-resolved optical mammography of the uncompressed breast", Platform Presentation, OSA Biomedical Optics Topical Meetings, Fort Lauderdale, March 2006

"The Development of 3D Optical Tomography for the Detection of Breast Cancer" Platform Presentation, Rank Prize Fund Conference, July 2005

”Dipole Source Localisation in a realistically shaped head phantom with commercially available head-nets” Poster Presentation, 8th Annual Meeting of the Organisation of Human Brain Mapping, NYC, June 2003

“A Potential Method for Imaging Neuronal Depolarisation in the brain by Electrical Impedance Tomography” Poster Presentation, 4th International conference on Bioelectromagnetism, Montreal, June 2002

“Electrical Impedance Tomography of Brain Function-Overview and Technical Considerations” Platform presentation , 4th International conference on Bioelectromagnetism, Montreal, Canada, June 2002