Jeremy C. Hebden Ph.D.

Jeremy C. Hebden

Professor Jem Hebden, Ph.D.
Head of Department

University College London
Department of Medical Physics & Bioengineering
Malet Place Engineering Building
London WC1E 6BT
UK

Phone: (44-20) 7679-0280

Fax: (44-20) 7679-0255

Email: jem AT medphys.ucl.ac.uk

Education

B.Sc. (Physics) Imperial College, London, UK (1981).
Ph.D. (Astronomy) Imperial College, London, UK (1984).

Research Interests

Optical imaging through turbulent and dense random media.
Time-of-flight measurement and imaging applications.
Development and application of Optical Tomography and Topography.
Medical and astronomical imaging methods and systems.

Current research activity involves the development of an optical instrument for imaging the brains of newborn infants using picosecond pulses of light. The device known as MONSTIR employs 32 time-resolved detectors to record the temporal distribution of near-infrared light as it passes through the brain. By using appropriate wavelengths sensitive to absorption by haemoglobin, images will reveal the cerebral oxygenation and haemodynamics of infants suspected of suffering hypoxic-ischaemic brain injury during birth. Early diagnosis will hopefully lead to development of more effective procedures to reduce the incidence of permanent brain damage. The instrument is also being evaluated as a potential means of identifying and specifying breast disease. Please click on the links below for more information about MONSTIR or about the other activities of the Biomedical Optics Research Laboratory at University College London.

The MONSTIR Imaging System
The Biomedical Optics Research Laboratory
The Department of Medical Physics & Bioengineering

Non-Research Activities

Intercalated medical student Tutor (Academic and Admissions).
Medical Physics undergraduate project coordinator.
Course organiser and lecturer on Medical Physics course PHAS3893.
Lecturer on Medical Physics courses PHAS1882, PHAS2881 and PHAS3891.
Webmaster for BORL website.

Recent Publications (Since 1/1/95)

J. C. Hebden, "Imaging through scattering media using characteristics of the temporal distribution of transmitted laser pulses," Optics and Laser Technology, 27, 263-268. 1995
J. C. Hebden, D. J. Hall and D. T. Delpy, "Spatial resolution performance of a time resolved imaging system using temporal extrapolation," Medical Physics, 22, 201-208. 1995 Download PDF file.
J. C. Hebden and A. H. Gandjbakhche, "Experimental validation of an elementary formula for estimating the spatial resolution for optical transillumination imaging," Medical Physics, 22, 1271-1272. 1995 Download PDF file.
J. C. Hebden, D. J. Hall, M. Firbank and D. T. Delpy, "Time resolved optical imaging of a solid tissue-equivalent phantom," Applied Optics, 34, 8038-8047. 1995 Download PDF file.
J. C. Hebden and S. R. Arridge, "Imaging through scattering media using an analytical model of perturbation amplitudes in the time domain," Applied Optics, 35, 6788-6796. 1996 Download PDF file.
J. C. Hebden, S. R. Arridge and D. T. Delpy, "Optical imaging in medicine I: experimental techniques," Physics in Medicine and Biology, 42, 825-840. 1997 Download PDF file.
S. R. Arridge and J. C. Hebden, "Optical imaging in medicine II: modelling and reconstruction," Physics in Medicine and Biology, 42, 841-854. 1997 Download PDF file.
D. J. Hall, J. C. Hebden and D. T. Delpy, "Evaluation of spatial resolution as a function of thickness for a time resolved optical imaging system," Medical Physics, 24, 361-368. 1997 Download PDF file.
J. C. Hebden, M. Tziraki and D. T. Delpy, "An evaluation of the temporally extrapolated absorbance method for dual-wavelength imaging through tissue-like scattering media," Applied Optics, 36, 3802-3810. 1997 Download PDF file.
D. J. Hall, J. C. Hebden and D. T. Delpy, "Imaging very low contrast objects in breast-like scattering media using a time resolved imaging method," Applied Optics, 36, 7270-7276. 1997 Download PDF file.
J. C. Hebden and D. T. Delpy, "Diagnostic imaging with light," British Journal of Radiology, 70, S206-S214. 1997
A. H. Gandjbakhche, V. Chernomordik, J. C. Hebden and R. Nossal, "Time-dependent contrast functions for quantitative imaging in time-resolved transillumination experiments," Applied Optics, 37, 1973-1981. 1998 Download PDF file.
J. C. Hebden, F. E. W. Schmidt, M. E. Fry, M. Schweiger, E. M. C. Hillman, D. T. Delpy and S. R. Arridge, "Simultaneous reconstruction of absorption and scattering images using multi-channel measurement of purely temporal data," Optics Letters, 24, 534-536. 1999 Download PDF file.
V. V. Chernomordik, A. H. Gandjbakhche, J. C. Hebden and G. Zaccanti, "Effect of lateral boundaries on contrast functions in time-resolved transillumination measurements," Medical Physics, 26, 1822-1831. 1999 Download PDF file.
F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Review of Scientific Instruments, 71, 256-265. 2000 Download PDF file.
S. R. Arridge, J. C. Hebden, M. Schweiger, F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, H. Dehghani and D. T. Delpy, "A method for 3D time-resolved optical tomography," International Journal for Imaging Systems and Technology, 11, 2-11. 2000 Download PDF file.
F. E. W. Schmidt, J. C. Hebden, E. M. C. Hillman, M. E. Fry, M. Schweiger, H. Dehghani and D. T. Delpy, "Multiple slice imaging of a tissue-equivalent phantom using time-resolved optical tomography", Applied Optics, 39, 3380-3387. 2000 Download PDF file.
E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani and D. T. Delpy, "Calibration techniques and datatype extraction for time-resolved optical tomography," Review of Scientific Instruments, 71(9), 3415-3427. 2000 Download PDF file.
E. M. C. Hillman, J. C. Hebden, M. Schweiger, H. Dehghani, F. E. W. Schmidt, D. T. Delpy and S. R. Arridge, "Time resolved optical tomography of the human forearm," Physics in Medicine and Biology, 46, 1117-1130. 2001 Download PDF file.
J. C. Hebden, H. Veenstra, H. Dehghani, E. M. C. Hillman, M. Schweiger, S. R. Arridge and D. T. Delpy, "Three dimensional time-resolved optical tomography of a conical breast phantom," Applied Optics, 40, 3278-3287. 2001 Download PDF file.
J. C. Hebden, A. Gibson, R. Md. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek and J. S. Wyatt, "Three-dimensional optical tomography of the premature infant brain," Physics in Medicine and Biology, 47, 4155-4166. 2002 Download PDF file.
J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. Md. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti and F. Martelli, "Assessment of an in situ temporal calibration method for time-resolved optical tomography," Journal of Biomedical Optics, 8, 87-92. 2003 Download PDF file.
A. Gibson, J. Riley, M. Schweiger, J. C. Hebden, S. R. Arridge, and D. T. Delpy, "A method for generating patient-specific finite element meshes for head modelling," Physics in Medicine and Biology, 48, 481-495. 2003 Download PDF file.
J. C. Hebden, "Advances in optical imaging of the newborn infant brain," Psychophysiology, 40, 501-510. 2003 Download PDF file.
J. C. Hebden, D. A. Boas, J. S. George, and A. J. Durkin, "Topics in biomedical optics: introduction," Applied Optics, 42, 2869-2870. 2003 Download PDF file.
A. Gibson, R. Yusof, H. Dehghani, J. Riley, N. Everdell, R. Richards, J. C. Hebden, M. Schweiger, S. R. Arridge, and D. T. Delpy, "Optical tomography of a realistic neonatal head phantom," Applied Optics, 42, 3109-3116. 2003 Download PDF file.
L. Martí-Lopez, J. Bouza-Domínguez, J, C. Hebden, S. R. Arridge and R. A. Martínez-Celorio, "Validity conditions for radiative transfer equation," Journal of the Optical Society of America A, 20, 2046-2056. 2003 Download PDF file.
J. C. Hebden, A. Gibson, T. Austin, R. Yusof, N. Everdell, D. T. Delpy, S. R. Arridge, J. H. Meek and J. S. Wyatt, "Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography," Physics in Medicine and Biology, 49, 1117-1130. 2004 Download PDF file.
J. C. Hebden, J. J. Garcia Guerrero, V. Chernomordik and A. H. Gandjbakhche, "Experimental evaluation of an anisotropic scattering model of a slab geometry," Optics Letters, 29, 2518-2520. 2004 Download PDF file.
L. Martí-Lopez, J. Bouza-Domínguez and J. C. Hebden, "Interpretation of the failure of the diffuse approximation near to a point source in terms of nonzero ray divergence," Optics Communications, 242, 23-43. 2004 Download PDF file.
J. C. Hebden, T. D. Yates, A. Gibson, N. Everdell, S. R. Arridge, D. W. Chicken, M. Douek and M. R. S. Keshtgar, "Monitoring recovery after laser surgery of the breast with optical tomography: a case study," Applied Optics, 44, 1898-1904. 2005 Download PDF file.
L. Mart�-L�pez, J. Bouza-Dom�nguez, R. A. Mart�nez-Celorio and J. C. Hebden, "Validation of radiative transfer equations for media with variable refractive index," Telecommunications and Radio Engineering, 64(8), 615-619, 2005.
A. P. Gibson, J. C. Hebden, and S. R. Arridge, "Recent advances in diffuse optical imaging," Physics in Medicine and Biology, 50, R1-R43. 2005 Download PDF file.
A. P. Gibson, J. C. Hebden, J. Riley, N. Everdell, M. Schweiger, S. R. Arridge, and D. T. Delpy, "Linear and non-linear reconstruction for optical tomography of phantoms with non-scattering regions," Applied Optics, 44, 3925-3936. 2005 Download PDF file.
T. D. Yates, J. C. Hebden, A. P. Gibson, N. L. Everdell, S. R. Arridge, and M. Douek, "Optical tomography of the breast using a multi-channel time-resolved imager," Physics in Medicine and Biology, 50, 2503-2517. 2005 Download PDF file.
T. D. Yates, J. C. Hebden, A. P. Gibson, L. Enfield, N. L. Everdell, S. R. Arridge, and D. T. Delpy, "Time-resolved optical mammography using a liquid coupled interface," Journal of Biomedical Optics, 10, 054011. 2005
N. L. Everdell, A. P. Gibson, I. D. C. Tullis, T. Vaithianathan, J. C. Hebden, and D. T. Delpy, "A frequency multiplexed near infrared topography system for imaging functional activation in the brain," Review of Scientific Instruments, 76, 093705. 2005 Download PDF file.
D. Passos, J. C. Hebden, P. N. Pinto, and R. Guerra, "A tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution," Journal of Biomedical Optics, 10, 064036. 2005 Download PDF file.
A. P. Gibson, T. Austin, N. L. Everdell, M. Schweiger, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, "Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate," Neuroimage, 30, 521-528. 2006 Download PDF file
L. Martí-Lopez, J. C. Hebden, and J. Bouza-Domínguez, "Estimates of minimum pulse width and maximum modulation frequency for diffusion optical tomography," Optics and Lasers in Engineering, 44, 1172-1184. 2006
T. Binzoni, C. Courvoisier, R. Giust, G. Tribillon, T. Gharbi, J. C. Hebden, T. S. Leung, J. Roux, and D.T. Delpy, "Anisotropic photon migration in human skeletal muscle," Physics in Medicine and Biology, 51, N79-N90. 2006 Download PDF file
T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt. "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage, 31, 1426-1433. 2006 Download PDF file
I. Nissilä, J. C. Hebden, D. Jennions, J. Heino, M. Schweiger, K. Kotilahti, T. Noponen, A. Gibson, S Järvenpää, L. Lipiäinen, and T. Katila, "A comparison between a time-domain and a frequency-domain system for optical tomography," Journal of Biomedical Optics, 11, 064015, 2006 Download PDF file.
J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Physics in Medicine and Biology, 51, 5581-5590, 2006 Download PDF file.
L. Martí-Lopez, J. Bouza-Domínguez, R. A. Martínez-Celorio, and J. C. Hebden, "An investigation of the ability of modified radiative transfer equations to accommodate fundamental laws of geometrical optics," Optics Communications, 266, 44-49, 2006. Download PDF file.
L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Applied Optics, 46, 3628-3638, 2007. Download PDF file.
A. Blasi, S. Fox, N. Everdell, A. Volein, L. Tucker, G. Csibra, A. P. Gibson, J. C. Hebden, M. H. Johnson, and C. E. Elwell, "Investigation of depth dependent changes in cerebral haemodynamics during face perception in infants," Physics in Medicine and Biology, 52, 6849-6864. 2007 Download PDF file.
J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," European Radiology, 17, 2926-2933. 2007 Download PDF file.
D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Research and Treatment, 108, 9-22. 2008
C. S. Colley, J. C. Hebden, D. T. Delpy, A. D. Cambrey, R. A. Brown, E. A. Zibik, W. H. Ng, L. R. Wilson, and J. W. Cockburn, "Mid-infrared optical coherence tomography," Review of Scientific Instruments, Review of Scientific Instruments, 78, 123108. 2007 Download PDF file.
J. C. Hebden, J. Brunker, T. Correia, B. D. Price, A. P. Gibson, and N. Everdell, "An electrically-activated dynamic tissue-equivalent phantom for assessment of diffuse optical imaging systems," Physics in Medicine and Biology, 53, 329-337. 2008 Download PDF file.
Y. Minagawa-Kawai, K. Mori, J. C. Hebden, and E. Dupoux, "Optical imaging of infants' neurocognitive development: recent advances and perspectives," Journal of Neurobiology 68, 712-728. 2008
J. C. Hebden, T. Correia, I. Khakoo, A. P. Gibson, and N. Everdell, "A dynamic optical imaging phantom based on an array of semiconductor diodes," Physics in Medicine and Biology (in press).

Click here for a comprehensive and up-to-date list of publications produced by the Biomedical Optics Research Laboratory since 1986.

Last update: October 3, 2008